Tumor Escape and Progression under Immune Pressure
نویسندگان
چکیده
منابع مشابه
Tumor Escape and Progression under Immune Pressure
1Department of Microbiology and Immunology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA 2Department of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 1421, USA 3Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA 4Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA 5Department...
متن کاملTumor escape from immune surveillance.
The bases for an efficient anti-tumor immune response begin to be better defined. Nonetheless, neoplastic cells develop various strategies to escape immune surveillance, which are discussed here in order to better design the therapeutic possibilities of immune manipulation. The absence of specific tumor antigen as well as the weak expression of major histocompatibility complex (MHC) molecules h...
متن کاملTumor immune escape in acute myeloid leukemia
In this overview, we discuss the role of class II-associated invariant chain peptide (CLIP) in acute myeloid leukemia (AML), one of the few tumors expressing HLA class II. The clinical impact, function and regulation of CLIP expression on leukemic cells is addressed, indicating its potential as immunotherapeutic target in AML.
متن کاملA Brief Introduction: from Immune Surveillance to Tumor-immune Escape
Los tumores deben evadir la respuesta inmunológica para ser clínicamente detectables en el paciente. A estos fines, las células cancerosas han desarrollado múltiples estrategias para eludir el ataque inmunológico. Estos mecanismos conspiran en estadíos avanzados de un tumor limitando la habilidad del sistema inmune para inhibir el crecimiento tumoral y la efectividad de estrategias de inmunoter...
متن کاملFrom tumor cell metabolism to tumor immune escape.
Tumorigenesis implies adaptation of tumor cells to an adverse environment. First, developing tumors must acquire nutrients to ensure their rapid growth. Second, they must escape the attack from the host immune system. Recent studies suggest that these phenomena could be related and that tumor cell metabolism may propel tumor immune escape. Tumor cell metabolism tends to avoid mitochondrial acti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical and Developmental Immunology
سال: 2012
ISSN: 1740-2522,1740-2530
DOI: 10.1155/2012/641079